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. 2022 Jan 6;12:726406. doi: 10.3389/fimmu.2021.726406

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Copyright © 2022 Avery, Robertson, Wu, Roy, Chauvin, Perkey, Vanderbeck, Maillard and Burkhardt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bone marrow of X-MAID mice shows a depleted lymphocyte progenitor population. Bone marrow cells from 3-5 week-old WT or X-MAID male mice were harvested, counted, and processed for flow cytometry. (A) Proportion and absolute number of hematopoietic stem cells (HSC) (CD150⁺CD48^–) displayed as gated on Lin^–Sca1⁺Ckit⁺ (LSK) population. (B) Proportion and absolute number of common lymphoid progenitors (CLP) (Flt3⁺IL7Rα⁺) displayed are gated on Lin^–Sca1^LOWCkit^LOW. (C) Proportion and absolute number of granulocyte/macrophage progenitors (GMP) (%FcγRII/III⁺CD150^–) displayed are gated on Lin^–Sca1^–Ckit⁺CD41^–. Data represent means ± StDev, with each point representing an individual mouse. Statistics were calculated using a Student’s t test, *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001.