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Performance comparison between CRISPR/Cas12a RR and DNA sequencing for STR-resistant (K88R) detection in clinical samples.
| Methods | CRISPR/Cas12a RR |
Comparison of two methods |
||||
| DNA sequencing | Positive | Negative | Total | Sensitivity (%) | Specificity (%) | Kappa |
| Positive | 20 | 0 | 20 | 100 | 100 | 1.00 |
| Negative | 0 | 20 | 20 | |||
| Total | 20 | 20 | 40 | |||
K88R, Lys88Arg nucleic acids sites in M.tb rpsl STR-resistant gene.
