Table 3.

Univariate and multifactorial logistic regression analysis of risk factors for Lymph node metastases in patients with osteosarcoma.

Variables	Univariate OR (95% CI)	p value	Multivariate OR (95% CI)	p value
Age (years)	1.011 (1.004–1.018)	<0.01	0.993 (0.982–1.004)	0.397
Survival time (month)	0.983 (0.974–0.992)	<0.001	0.998 (0.987–1.010)	0.788
Race
White	Reference	Ref	Ref	Ref
Black	1.248 (0.766–3.033)	0.374	/	/
Other	0.993 (0.537–1.835)	0.982	/	/
Sex
Male	Ref	Ref	Ref	Ref
Female	1.163 (0.810–1.671)	0.412	/	/
Primary site
Limb bones	Ref	Ref	Ref	Ref
Axis of a bone	1.675 (1.133–2.478)	<0.05	0.946 (0.517–1.731)	0.857
Other	1.286 (0.671–2.466)	0.449	1.840 (0.806–4.198)	0.148
Grade
Well-differentiated	Ref	Ref	Ref	Ref
Moderately differentiated	1.282 (0.110–14.893)	0.843	/	/
Poorly differentiated	2.569 (0.334–19.741)	0.364	/	/
Undifferentiated; anaplastic	2.473 (0.328–18.673)	0.380	/	/
Unknown	6.332 (0.840–47.705)	0.073	/	/
Laterality
Left	Ref	Ref	Ref	Ref
Right	1.395 (0.930–2.091)	0.108	1.477 (0.920–2.371)	0.106
Other	1.848 (1.102–3.101)	<0.05	1.113 (0.536–2.310)	0.774
T
T1	Ref	Ref	Ref	Ref
T2	1.121 (0.657–1.912)	0.675	0.960 (0.540–1.707)	0.889
T3	2.528 (0.900–7.101)	0.078	1.473 (0.476–4.559)	0.502
TX	7.933 (4.780–13.167)	<0.001	3.062 (1.710–5.483)	<0.001
M
M0	Ref	Ref	Ref	Ref
M1	2.506 (1.710–3.673)	<0.001	2.890 (1.463–5.709)	<0.01
Surgery
No	Ref	Ref	Ref	Ref
Yes	0.197 (0.135–0.287)	<0.001	0.418 (0.247–0.706)	<0.01
Radiation
No	Ref	Ref	Ref	Ref
Yes	1.524 (0.936–2.481)	0.091	/	/
Chemotherapy
No	Ref	Ref	Ref	Ref
Yes	0.289 (0.199–0.421)	<0.001	0.475 (0.276–0.819)	<0.01
Bone metastases
No	Ref	Ref	Ref	Ref
Yes	3.260 (1.652–6.436)	<0.01	1.257 (0.570–2.772)	0.571
Unknown	32.490 (16.267–64.892)	<0.001	2.159 (0.483–9.659)	0.314
Lung metastases
No	Ref	Ref	Ref	Ref
Yes	2.938 (1.887–4.573)	<0.001	0.902 (0.449–1.812)	0.771
Unknown	45.225 (21.360–95.754)	<0.001	9.407 (1.955–45.261)	<0.01