Tabla 2.
Principales interacciones farmacológicas que se identificaron en la prescripción médica. Muestra las posibles interacciones farmacológicas medicamentomedicamento que se presentaron durante el periodo de revisión
| # | Incidencia de interacciones medicamento-medicamento graves | Mecanismo de interacción | Frecuencia | Porcentaje | # | Incidencia de interacciones medicamento-medicamento graves | Mecanismo de interacción | Frecuencia | Porcentaje |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Acenocumarol-levotiroxina | FC | 6 | 2.8% | 29 | Furosemida-amikacina | FD | 14 | 6.6% |
| 2 | Acenocumarol-amiodarona | FC | 10 | 4.7% | 30 | Furosemida-vancomicina | FD | 2 | 0.9% |
| 3 | Acenocumarol-rifampicina | FC | 1 | 0.5% | 31 | Furosemida-AAS | FC | 5 | 2.4% |
| 4 | Acenocumarol-moxifloxacino | FC | 2 | 0.9% | 32 | Clopidogrel-amlodipino | FC | 11 | 5.2% |
| 5 | Acenocumarol-omeprazol | FC | 2 | 0.9% | 33 | Clopidogrel-omeprazol | FC | 19 | 9.0% |
| 6 | Acenocumarol-ketorolaco | FD | 1 | 0.5% | 34 | Espironolactona-IECA | FD | 4 | 1.9% |
| 7 | Acenocumarol-clopidogrel | FC | 2 | 0.9% | 35 | Atorvastatina-colchicina | FC | 6 | 2.8% |
| 8 | Amiodarona-clortalidona | FD | 1 | 0.5% | 36 | Atorvastatina-diltiazem | FC | 1 | 0.5% |
| 9 | Amiodarona-digoxina | FC | 11 | 5.2% | 37 | Atorvastatina-rifampicina | FD | 1 | 0.5% |
| 10 | Amiodarona-hidroclorotiazida | FD | 1 | 0.5% | 38 | Amlodipino-Simvastatina | FC | 2 | 0.9% |
| 11 | Amiodarona-levofloxacino | FD | 5 | 2.4% | 39 | Carbonato de calcio-levotiroxina | FC | 1 | 0.5% |
| 12 | Amiodarona-propafenona | FC | 1 | 0.5% | 40 | Enalapril-losartán | FD | 1 | 0.5% |
| 13 | Amiodarona-moxifloxacino | FD | 2 | 0.9% | 41 | Haloperidol-quetiapina | FD | 1 | 0.5% |
| 14 | Amiodarona-furosemida | FD | 6 | 2.8% | 42 | Hidroxicloroquina-leflunomida | FD | 1 | 0.5% |
| 15 | Amiodarona-sulfametoxazol/trimetoprima | FD | 1 | 0.5% | 43 | Moxifloxacino-insulina humana acción rápida | FD | 1 | 0.5% |
| 16 | Amiodarona-risperidona | FD | 1 | 0.5% | 44 | Captopril-alopurinol | FD | 8 | 3.8% |
| 17 | Amiodarona-haloperidol | FD | 2 | 0.9% | 45 | Ivabradina-metoprolol | FD | 2 | 0.9% |
| 18 | Amiodarona-tacrolimús | FD | 2 | 0.9% | 46 | Ivabradina-diltiazem | FC | 30 | 14.2% |
| 19 | Amiodarona-amlodipino | FC | 2 | 0.9% | 47 | Prazosina-nifedipino | FD | 1 | 0.5% |
| 20 | Amiodarona-colchicina | FC | 1 | 0.5% | 48 | Prazosina-metoprolol | FD | 1 | 0.5% |
| 21 | Amiodarona-nifedipino | FD | 1 | 0.5% | 49 | Rifampicina-prednisona | FD | 1 | 0.5% |
| 22 | Paroxetina-metoprolol | FC | 1 | 0.5% | 50 | Omeprazol-sulfato ferroso | FD | 3 | 1.4% |
| 23 | Digoxina-metoprolol | FC | 14 | 6.6% | 51 | Levofloxacino-prednisona | FD | 1 | 0.5% |
| 24 | Digoxina-verapamilo | FC | 1 | 0.5% | 52 | Metoclopramida-sertralina | FD | 1 | 0.5% |
| 25 | Digoxina-propranolol | FC | 1 | 0.5% | 53 | Mirtazapina-escitalopram | FD | 1 | 0.5% |
| 26 | Digoxina-espironolactona | FC | 8 | 3.8% | 54 | Enoxaparina sódica-claritromicina | FD | 4 | 1.9% |
| 27 | Digoxina-omeprazol | FC | 1 | 0.5% | 55 | Enoxaparina sódica-ceftriaxona | FD | 1 | 0.5% |
| 28 | Digoxina-alprazolam | FC | 2 | 0.9% | 56 | Enoxaparina sódica-sulfametoxazol | FD | 1 | 0.5% |
| Total: 212 | 100% | ||||||||
FC: farmacocinética; FD: farmacodinámica; AAS: ácido acetilsalicílico; IECA: inhibidor de la enzima convertidora de angiotensina.