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. 2021 Dec 10;17(7):1397–1403. doi: 10.4103/1673-5374.330592

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Copyright: © Neural Regeneration Research

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Utilization of UDP-GlcNAc synthesized from glucose in protein glycosylation.

UDP-GlcNAc can be directly used to modify a protein chain to become O-GlcNAcylated protein. UDP-GlcNAc is also used to build complex glycan chains and attach them to a nascent protein chain mainly via either nitrogen of Asn or oxygen of Ser/Thr to become N- or O-glycosylated protein. ADP: Adenosine diphosphate; ATP: adenosine 5′-triphosphate; OGA: O-GlcNAcase; OGT: O-GlcNAc transferase; UDP: uridine diphosphate.