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. 2021 Dec 10;17(7):1454–1461. doi: 10.4103/1673-5374.330588

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Primary structures of Homer proteins.

All Homer proteins share a common enabled/vasodilator-stimulated phosphoprotein homology 1 (EVH1) domain at their amino terminal, as well as a carboxy-terminal coiled-coil (CC) domain and leucine zipper (Lzip) motif. The EVH1 domain binds the proline-rich sequence PPXXF in various proteins, such as metabotropic glutamate receptors (mGluR), inositol trisphosphate receptors (IP3R), and transient receptor potential canonical (TRPC) channels. The CC domain mainly mediates self-assembly or multimerization among long Homers.