Table 1.

Homer protein family structural characteristics

Homers	Homer subtypes	Domain composition	Main function
Long homers	Homer1b–d, Homer2a/b, Homer3a/b	Amino terminal: enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) homology 1 (EVH1) domain carboxy-terminal: coiled-coil (CC) domain	Form diverse protein complexes; Facilitate intracellular signaling transduction
Short homers	Homer1a, Homer2c/d, Homer3c	Amino-terminal: enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) homology 1 (EVH1) domain	Disrupt diverse protein complexes; Regulate intracellular signaling transduction