. 2022 Jan 19;7(3):268–276. doi: 10.1001/jamacardio.2021.5617

Table 2. Adjusted Association of Baseline N-Terminal Pro–Brain Natriuretic Peptide (NT-proBNP) and Blood Pressure With Adverse Pregnancy Outcome (APO)^a^,^b.

Measure	Adjusted OR (95% CI)
Measure	No APO (n = 3185)	Any APO (n = 909)	HDP (n = 544)	Spontaneous preterm birth (n = 199)	SGA (n = 170)
NT-proBNP, median (IQR), pg/mL	63.0 (41.0-95.0)	56.0 (35.0-89.0)	52.0 (34.0-83.0)	61.0 (33.0-104.0)	61.0 (39.0-95.0)
NT-proBNP, per doubling in value	1 [Reference]	0.90 (0.82-0.98)^c	0.81 (0.73-0.91)^c	1.00 (0.85-1.18)	1.04 (0.87-1.25)
NT-proBNP, per doubling in value, controlling for systolic blood pressure	1 [Reference]	0.91 (0.84-1.00)^c	0.84 (0.75-0.94)^c	1.00 (0.84-1.18)	1.05 (0.88-1.26)

Abbreviations: HDP, hypertensive disorders of pregnancy; OR, odds ratio; SGA, small for gestational age.

^{^a}

Adjusted for age, race and ethnicity, body mass index, smoking, and aspirin use.

^{^b}

This characteristic is included in statistical models after a logarithm transformation (base, 2). ORs for log-transformed quantities are interpreted on the multiplicative scale.

^{^c}

P < .05.

Table 2. Adjusted Association of Baseline N-Terminal Pro–Brain Natriuretic Peptide (NT-proBNP) and Blood Pressure With Adverse Pregnancy Outcome (APO)a,b.

Table 2. Adjusted Association of Baseline N-Terminal Pro–Brain Natriuretic Peptide (NT-proBNP) and Blood Pressure With Adverse Pregnancy Outcome (APO)^a^,^b.