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. Author manuscript; available in PMC: 2022 Jan 20.
Published in final edited form as: Am J Obstet Gynecol. 2018 Feb 17;218(6):604.e1–604.e8. doi: 10.1016/j.ajog.2018.02.009

Table 4.

Incremental yield of multiple biopsies in risk strata

Stratum (Colposcopy impression/ cytology/
HPV16)		 Women in
stratum		 Disease yield
first biopsy		 Disease yield
all biopsies		 Incremental
yield		 Incremental
sensitivity
High grade/ HSIL/ HPV16+ 58 66% 78% 12% 15%
High grade/ <HSIL/ HPV16+ 26 50% 77% 27% 35%
Low grade/ HSIL/ HPV16+ 26 54% 73% 19% 26%
High grade/ HSIL/ HPV16− 51 41% 63% 22% 35%
Low grade/ <HSIL/ HPV16+ 57 35% 51% 16% 31%
Low grade/ HSIL/ HPV16− 53 19% 42% 23% 55%
High grade/ <HSIL/ HPV16− 76 12% 37% 25% 68%
Low grade/ <HSIL/ HPV16− 191 11% 19% 8% 42%
Normal or acetowhitening/ <HSIL/ HPV16− 81 2% 4% 2% 50%

HSIL: High grade squamous intraepithelial lesion; high-risk categories are shown in bold; disease indicates histological HSIL; incremental yield indicates the absolute difference in yield from all biopsies and the first biopsy; incremental sensitivity indicates the relative increase in detection from the first biopsy to all biopsies