Effects of RH on adrenal CAT release evoked by membrane depolarization and activation of Ach receptors: (a) sequence of infusions applied to elicit CAT release from the LAG, (b) basal release of CAT before each agonist infusion, (c) CAT release evoked by repeated KCl infusions and (d) randomized Ach doses. Sigmoidal curves were fitted to Saline (——) and RH (······) data, respectively. Saline (n = 3) and RH (n = 6).
CAT: catecholamine; RH: recurrent hypoglycaemia; EPI: epinephrine; NE: norepinephrine; LAG: left adrenal gland; Ach: acetylcholine; Nico: nicotine; Pilo: pilocarpine.
*P < 0.05, NE release evoked by KCl infusion, 1 versus 2 and 3.