Table 2.
Correlation analysis between GINS2 and related gene markers of immune cells in TIMER.
| Description | Gene markers | LIHC | |||
|---|---|---|---|---|---|
| None | Purity | ||||
| Cor | P | Cor | P | ||
| CD8+ T cell | CD8A | 0.131 | 1.17E-02* | 0.268 | 4.37E-07* |
| CD8B | 0.167 | 1.26E-03* | 0.296 | 2.01E-08* | |
| T cell(general) | CD3D | 0.221 | 1.82E-05* | 0.371 | 1.05E-12* |
| CD3E | 0.082 | 1.14E-01 | 0.259 | 1.12E-06* | |
| CD2 | 0.114 | 2.79E-02* | 0.279 | 1.42E-07* | |
| B cell | CD19 | 0.162 | 1.79E-03* | 0.255 | 1.66E-06* |
| CD79A | 0.060 | 2.48E-01 | 0.191 | 3.55E-04* | |
| Monocyte | CD86 | 0.203 | 8.65E-05* | 0.374 | 7.02E-13* |
| CD115(CSF1R) | 0.090 | 8.48E-02 | 0.249 | 2.71E-06* | |
| TAM | CCL2 | 0.011 | 8.29E-01 | 0.145 | 6.80E-03* |
| CD68 | 0.078 | 1.34E-01 | 0.180 | 7.79E-04* | |
| IL10 | 0.120 | 2.07E-02* | 0.248 | 3.24E-06* | |
| M1 Macrophage | INOS(NOS2) | -0.002 | 9.76E-01 | 0.007 | 8.93E-01 |
| IRF5 | 0.345 | 7.81E-12* | 0.348 | 2.76E-11* | |
| COX2(PTGS2) | -0.020 | 6.96E-01 | 0.119 | 2.77E-02* | |
| M2 Macrophage | CD163 | 0.025 | 6.35E-01 | 0.154 | 4.21E-03* |
| VSIG4 | 0.065 | 2.09E-01 | 0.199 | 2.03E-04* | |
| MS4A4A | 0.029 | 5.80E-01 | 0.176 | 1.01E-03* | |
| Neutrophils | CD66b(CEACAM8) | 0.078 | 1.35E-01 | 0.120 | 2.62E-02* |
| CD11b(ITGAM) | 0.272 | 1.13E-07* | 0.378 | 3.89E-13* | |
| CCR7 | -0.027 | 6.02E-01 | 0.127 | 1.85E-02* | |
| Natural Killer cell | KIR2DL1 | -0.028 | 5.95E-01 | -0.044 | 4.13E-01 |
| KIR2DL3 | 0.116 | 2.53E-02* | 0.157 | 3.53E-03* | |
| KIR2DL4 | 0.191 | 2.09E-04* | 0.230 | 1.58E-05* | |
| KIR3DL1 | -0.002 | 9.65E-01 | 0.008 | 8.79E-01 | |
| KIR3DL2 | 0.049 | 3.43E-01 | 0.100 | 6.36E-02 | |
| KIR3DL3 | 0.000 | 9.92E-01 | 0.014 | 8.00E-01 | |
| KIR2DS4 | 0.036 | 4.94E-01 | 0.032 | 5.53E-01 | |
| Dendritic cell | HLA-DPB1 | 0.130 | 1.24E-02 | 0.274 | 2.38E-07* |
| HLA-DQB1 | 0.145 | 5.19E-03* | 0.288 | 5.03E-08* | |
| HLA-DRA | 0.110 | 3.43E-02* | 0.247 | 3.31E-06* | |
| HLA-DPA1 | 0.090 | 8.32E-02 | 0.236 | 9.70E-06* | |
| BDCA-1(CD1C) | -0.026 | 6.13E-01 | 0.083 | 1.22E-01 | |
| BDCA-4(NRP1) | 0.058 | 2.65E-01 | 0.088 | 1.04E-01 | |
| CD11c(ITGAX) | 0.194 | 1.75E-04* | 0.335 | 1.71E-10* | |
| Th1 cell | T-bet(TBX21) | 0.013 | 8.03E-01 | 0.134 | 1.25E-02* |
| STAT4 | 0.173 | 8.59E-04* | 0.252 | 2.22E-06* | |
| STAT1 | 0.249 | 1.31E-06* | 0.305 | 7.48E-09* | |
| IFN-y(IFNG) | 0.221 | 1.77E-05* | 0.310 | 3.88E-09* | |
| TNF-a(TNF) | 0.149 | 4.12E-03* | 0.289 | 4.88E-08* | |
| Th2 cell | GATA3 | 0.102 | 4.92E-02* | 0.253 | 1.91E-06* |
| STAT6 | 0.038 | 4.60E-01 | 0.026 | 6.36E-01 | |
| STAT5A | 0.240 | 2.99E-06* | 0.306 | 6.77E-09* | |
| IL13 | 0.123 | 1.75E-02* | 0.123 | 2.27E-02* | |
| Tfh cell | BCL6 | 0.011 | 8.31E-01 | 0.015 | 7.79E-01 |
| IL21 | 0.078 | 1.34E-01 | 0.130 | 1.58E-02* | |
| Th17 cell | STAT3 | 0.030 | 5.61E-01 | 0.076 | 1.61E-01 |
| IL17A | 0.001 | 9.84E-01 | 0.019 | 7.28E-01 | |
| Treg cell | FOXP3 | 0.116 | 2.52E-02* | 0.202 | 1.53E-04* |
| CCR8 | 0.203 | 8.53E-05* | 0.297 | 1.82E-08* | |
| STAT5B | 0.135 | 9.18E-03* | 0.103 | 5.68E-02 | |
| TGFβ(TGFB1) | 0.138 | 7.79E-03* | 0.241 | 6.03E-06* | |
| T cell exhaustion | PD-1(PDCD1) | 0.217 | 2.38E-05* | 0.340 | 8.68E-11* |
| CTLA4 | 0.230 | 7.77E-06* | 0.362 | 3.90E-12* | |
| LAG3 | 0.292 | 1.16E-08* | 0.356 | 9.35E-12* | |
| TIM-3(HAVCR2) | 0.229 | 8.81E-06* | 0.404 | 5.29E-15* | |
TIMER: Correlation module analyzes the expression between a pair of specific genes in HCC, together with the Spearman's rho value and estimated statistical significance. Options for partial correlation conditioned on tumor purity are also provided. Cor, R value of Spearman's correlation; None, correlation without adjustment. Purity, correlation adjusted by purity. * P < 0.05.