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. 2022 Jan 1;12(3):1388–1403. doi: 10.7150/thno.62514

Figure 6.

Figure 6

GDNP inhibited HFD mediated chronic inflammation and improves the life span of mice. A. Quantification of plasma levels of pro-inflammatory (IL-1β, IL-6 and TNF-α) and anti-inflammatory (IL-10) cytokines in lean and PBS- or GDNP-treated HFD-fed mice (n = 5/group). B. Cytokine array for skin tissue obtained from lean and PBS- or GDNP-treated HFD-fed mice. Pro-inflammatory cytokines spots/positions are indicated with red circles (n = 5/group). C. Quantification of inflammatory cytokines TNF-α and IL-6 by ELISA in skin tissues (n = 5/group). D. Representative images of the phenotypic changes induced by 12 months of HFD feeding. Note the changes in skin/fur color (red circle) and hair loss in PBS-treated HFD mice (upper row) compared to GDNP treated mice (lower row). E. Percentage survival during HFD feeding and treatment with GDNP vs PBS, compared to control lean animals. One-way ANOVA with the Bonferroni correction for multiple comparisons was used to calculate statistical significance. (p value *<0.05; **<0.01; ***<0.001)