Figure 1.

Schematic diagram of lymphatic transport in the CNS. (A) Lymphatic vessels near the cribriform plate. (B) Two uncertain pathways for CSF drainage at the base skull: the peripheral pathways (blue dashed box) and the base MLVS that overlap with the nerve anatomically (red dashed box). (C) Dorsal MLVs near sagittal sinus. (D) Overview of the lymphatic transport of CSF and ISF through the glymphatic system. Note: CN I, olfactory nerve; CN V, trigeminal nerve; CN IX, glossopharyngeal nerve; CN X, vagus nerve. Adapted with permission from Ref. 124 for A, copyright 2019 Nature Publishing Group; Ref. 125 for D, copyright 2013 American Association for the Advancement of Science. Created with BioRender.com.