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Probability of target attainment (PTA) at targets AUC0-24 ≥ 400 mg · h/liter and toxicity at AUC0-24 > 700 mg · h/liter for a patient with various weights (60 kg and 100 kg) and various degrees of renal function (CrCL of 30 ml/min and 100 ml/min) at steady state with various intermittent vancomycin dosing regimens. Gray area demonstrates the therapeutic window, the difference in the probability of attaining concentrations of efficacy and toxicity.
