TABLE 2.
Pharmacokinetic parameter estimates for final vancomycin PK modela
| Parameter | Mean | SD | Coefficient of variation (%) | Median | Shrinkage (%) |
|---|---|---|---|---|---|
| CL (liters/h) | 3.20 | 0.56 | 17.64 | 3.49 | 4.38 |
| CLrrt (liters/h) | 0.15 | 0.11 | 72.43 | 0.21 | 8.28 |
| Vc (liters) | 29.73 | 14.76 | 49.67 | 30.86 | 10.47 |
| kCP (h−1) | 0.94 | 1.15 | 122.14 | 0.31 | 13.69 |
| kPC (h−1) | 2.11 | 4.46 | 211.47 | 0.08 | 13.90 |
| Error model | Gamma = 3 (multiplicative) | ||||
a
CL, vancomycin clearance; CLrrt, vancomycin clearance while a patient is on renal replacement therapy; Vc, volume of distribution of the central compartment; kCP, constant for distribution of vancomycin from the central to the peripheral compartment; kPC, constant for distribution of vancomycin from the peripheral to the central compartment.