TABLE 3.

Comparison of vancomycin population PK in critically ill adult patients receiving ECMO and/or RRT^a

Study	Population [n]	No. of compartments	Vc (liters/kg)b	Vp (liters/kg)	Vss (liters/kg)	Q (liters/h)	CL (liters/h)	CLrrt (liters/h)
Current study	Critically ill adults, ECMO with and without RRT [22]	Two	0.39			Kpc 2.11 Kcp 0.94	3.20	0.15
Jung et al. (37)	Critically ill adults, ECMO without RRT [22]	Three	0.11	V2 0.29 V3 0.08	0.40	Q2VV 6.23 Q2VA 4.95 Q3 9.09	4.01
Lim et al. (24)	Critically ill adults [20]	Two	0.52	0.77	1.29	6.99	3.96
Donadello et al. (21)	Critically ill adults, ECMO and non-ECMO, include RRT [11]	Two	0.45	0.82	1.27	3.60	3.70	0.6*3.7 = 2.22
Wu et al. (22)	Critically ill adults, ECMO [22]	One			0.83		4.31
Mulla & Pooboni (23)	Critically ill neonates, children and adults, ECMO [45]	Two	0.37 for age > 4000 days	0.25	0.62	0.64	0.04*79 = 3.16
Moore et al. (15)	Critically ill adults, ECMO [14]	Two	0.25	0.34	0.59	11.2	2.83
Mahmoud et al. (38)	Critically ill adults, ECMO [8]	Three	0.16	Vp 0.39 Vecmo 0.002	0.56	9.1	6.89
Economou et al. (30)	Critically ill adults, PIRRT [11]	Two	0.45			Kpc 5.29 Kcp 5.97	2.15	ClPIRRT 3.47
Deldot et al. (18)	Critically ill adults, CVVHDF [10]	NCA			0.62	-		1.8

^aV_c, central volume of distribution; V_p, peripheral volume of distribution; V_ss, steady state volume of distribution; Q, intercompartmental rate constant; CL, clearance; CL_rrt, dialytic clearance; ECMO, extracorporeal membrane oxygenation; RRT, renal replacement therapy; PIRRT, prolonged intermittent renal replacement therapy; CVVHDF, continuous venovenous haemodiafiltration; NCA, noncompartmental analysis.

^bLiters/kg calculations were made based on reported mean weight from the respective study and assumes a linear relationship.