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. 2022 Jan 21;28(3):310–331. doi: 10.3748/wjg.v28.i3.310

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Proposed algorithm for hepatocellular carcinoma surveillance in non-alcoholic fatty liver disease patients based on future perspectives. HCC: Hepatocellular carcinoma; NAFLD: Non-alcoholic fatty liver disease; PNPLA3: Patatin-like phospholipase domain-containing protein 3; MiRNAs: Micro-RNAs; lnc-RNAs: Long non-coding-RNAs; ALP: Alkaline phosphatase; AFP: Alpha-fetoprotein; US: Ultrasonography; CT: Computer tomography; MRI: Magnetic resonance imaging; BMI: Body mass index.