Table 3.
Frequency of intrathecal IgG synthesis, oligoclonal IgG patterns, IgG CSF/serum ratios, intrathecal IgG fractions, absolute amount of locally produced IgG, and absolute IgG concentrations in the CSF and serum in group I
| Units | Total | ≤ 14 d | > 14 d | Acute B/SC subgroup | Acute PN/C/H subgroup | |
|---|---|---|---|---|---|---|
| Intrathecal IgG synthesis | ||||||
| OCB positive or IgG-IF ≥ 10% | Samples | 2/103 (1.9%) | 1/71 (1.4%) | 0/21 (0%) | 1/57 (1.8%) | 0/13 (0%) |
| OCB positive | Samples | 2/103 (1.9%) | 1/71 (1.4%) | 0/21 (0%) | 1/56 (1.8%) | 0/12 (0%) |
| OCB pattern 1 | Samples | 42/103 (40.8%) | 33/71 (46.5%) | 6/21 (28.6%) | 23/56 (41.1%) | 9/12 (75%) |
| OCB pattern 2 | Samples | 0/103 (0%) | 0/71 (0%) | 0/21 (0%) | 0/56 (0%) | 0/12 (0%) |
| OCB pattern 3 | Samples | 2/103 (1.9%) | 1/71 (1.4%) | 0/21 (0%) | 1/56 (1.8%) | 0/12 (0%) |
| OCB pattern 4 | Samples | 58/103 (56.3%) | 36/71 (50.7%) | 15/21 (71.4%) | 31/56 (55.4%) | 3/12 (25%) |
| OCB pattern 5 | Samples | 1/103 (1%) | 1/71 (1.4%) | 0/21 (0%) | 1/56 (1.8%) | 0/12 (0%) |
| OCB pattern 2 or 3 | Samples | 2/103 (1.9%) | 1/71 (1.4%) | 0/21 (0%) | 1/56 (1.8%) | 0/12 (0%) |
| OCB pattern 3 or 4 | Samples | 60/103 (58.3%) | 37/71 (52.1%) | 15/21 (71.4%) | 32/56 (57.1%) | 3/12 (25%) |
| OCB pattern 1, 4, or 5 | Samples | 101/103 (98.1%) | 70/71 (98.6%) | 21/21 (100%) | 32/56 (98.2%) | 3/12 (100%) |
| QIgG > Qlim(IgG) | Samples | 1/115 (1%) | 1/81 (1%) | 0/21 (0%) | 1/64 (1.6%) | 0/16 (0%) |
| QIgG, all LPs | – | 3.7 (0.9–22.4;115) | 3.8 (1–22.4;81) | 4.1 (1.2–6.8;21) | 3.85 (1.54–22.4;64) | 3.7 (0.96–12.1;16) |
| QIgG, if positive | – | 8.3 (8.3–8.3;1) | 8.3 (8.3–8.3;1) | n.a. (n.a.;0) | 8.25 (8.25–8.25;1) | n.a. (n.a.;0) |
| IgG-IF, all LPs | % IgG(CSF) | 0 (0–32.2;115) | 0 (0–32.2;81) | 0 (0–0;21) | 0 (0–32.2;64) | 0 (0–0;16) |
| IgG-IF, QIgG positives | % IgG(CSF) | 32.2 (32.2–32.2;1) | 32.2 (32.2–32.2;1) | n.a. (n.a.;0) | 32.2 (32.2–32.2;1) | n.a. (n.a.;0) |
| IgG-IF, > 10% | Samples | 1/115 (0.9%) | 1/81 (1.2%) | 0/21 (0%) | 1/64 (1.6%) | 0/16 (0%) |
| IgG-loc, all LPs | mg/l | 0 (0–38;115) | 0 (0–38;81) | 0 (0–0;21) | 0 (0–38;64) | n.a. (n.a.; 0) |
| IgG-loc, QIgG positives | mg/l | 38 (38–38;1) | 38 (38–38;1) | n.a. (n.a.;0) | 38 (38–38;1) | n.a. (n.a.;0) |
| IgG CSF, all LPs | mg/l | 40.4 (6.2–239;115) | 41.7 (8–239;81) | 40.4 (9.6–69;21) | 43.75 (12–239;64) | 34.95 (8–135;16) |
| IgG CSF, QIgG positives | mg/l | 118 (118–118;1) | 118 (118–118;1) | n.a. (n.a.;0) | 118 (118–118;1) | n.a. (n.a.;0) |
| IgG serum, all LPs | g/l | 11.3 (3.4–28.8;120) | 11.3 (3.4–21.1;81) | 10.7 (6.1–18.2;22) | 11.45 (3.4–21.1;64) | 11 (6.34–18.2;16) |
| IgG serum, QIgG positives | g/l | 14.3 (14.3–14.3;1) | 14.3 (14.3–14.3;1) | n.a. (n.a.;0) | 14.3 (14.3–14.3;1) | n.a. (n.a.;0) |
| IgG serum, elevated | Samples | 12/120 (10%) | 5/81 (6.2%) | 1/22 (4.5%) | 4/64 (6.3%) | 1/16 (6.3%) |
| Link index, all | Samples | 1/114 (1%) | 1/80 (1%) | 0/21 (0%) | 1/63 (1.6%) | 0/16 (0%) |
| Link index, if positive | Index | 1.1 (1.1–1.1;1) | 1.1 (1.1–1.1;1) | n.a. (n.a.;0) | 1.1 (1.1–1.1;1) | n.a. (n.a.;0) |
Quotients, indices, concentrations, and fractions are given as medians (with ranges and sample numbers in brackets). B/SC brain/spinal cord, PN/CN/H peripheral nerve/cranial nerve/headache only, OCB oligoclonal IgG bands, QIgG/A/M CSF/serum IgG/A/M ratio, IgG/A/M IF intrathecally produced IgG/IgA/IgM fraction; IgG/A/M loc locally (intrathecally) produced IgG/A/M; LP lumbar puncture