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. 2022 Jan 1;18(3):1134–1149. doi: 10.7150/ijbs.68091

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TBL1X rescues the effect of altered Flot2 expression on NPC cell migration and invasion. (A) Matrigel invasion analysis showed that oeTBL1X enhanced the invasion of 5-8FshFlot2 cells. (B) shTBL1X inhibited the invasion of 6-10B-Flot2 cells. (C) Wound-healing assay showed that oeTBL1X enhanced the migration 5-8FshFlot2 cells. (D) shTBL1X inhibited the migration of 6-10B-Flot2 cells. (E) Nude mouse metastasis assay showed the lung metastases via tail vein injection of 5-8Fcontrol, 5-8FshFlot2 or 5-8FshFlot2+oeTBL1X cells (n=6, respectively). (F) The number of lung metastases in mice. (G) Representative HE staining images of lung metastases resulting from 5-8Fcontrol, 5-8FshFlot2 or 5-8FshFlot2+oeTBL1X cell inoculations. The results are shown as means±SD. *P<0.05, **P<0.01, ***P<0.001.