Figure 3.

SOX8 reduced the uptake of albumin-bound paclitaxel by reducing the expression of SPARC. (A) Uptake of albumin-bound paclitaxel of SOX8 overexpression Panc-1 cells and SOX8 knock-down CFPAC-1 cells. (B) Western Blot analysis of albumin-bound paclitaxel taken into cells using anti-albumin antibody. (C) mRNA expression of SOX8/CAV1/SPARC in transcriptomic sequencing results. (D) mRNA expression 0f CAV1/SPARC in SOX8 overexpression Panc-1 cells and SOX8 knock-down CFPAC-1 cells. (E) Cell cycle and apoptosis of Panc-1-SOX8 and Panc-1 -SOX8-siSPARC. (F) Cell cycle and apoptosis of CFPAC-1-shSOX8 and CFPAC-1-shSOX8-SPARC. (G) Immunohistochemical co-localization of SOX8 and SPARC and H. Statistical Analysis,