Table 1.

Assessment of Acute GvHD: staging of severity for individual organs according to the different classifications.

Organ	Severity stage	Modified Glucksberg (Keystone aGvHD consensus) criteria and IBMTR criteria (66, 67)	MAGIC criteria (68)
Skin	0	No rash
	1	Rash <25% BSA
	2	Rash 25–50% BSA
	3	Rash >50% BSA
	4	Generalised erythroderma with bullous formation	Generalised erythroderma (>50% BSA) plus bullous formation and desquamation >5% BSA
Liver	0	Total serum bilirubin <2 mg/dL
	1	Total serum bilirubin 2–3 mg/dL
	2	Total serum bilirubin 3.1–6 mg/dL
	3	Total serum bilirubin 6.1–15 mg/dL
	4	Total serum bilirubin >15 mg/dL
Upper GI tract	0	No persistent nausea and no histologic evidence of GvHD in the stomach or duodenum	No or intermittent anorexia or nausea or vomiting*
	1	Persistent nausea with histologic evidence of GvHD in the stomach or duodenum	Persistent anorexia or nausea or vomiting*
Lower GI tract	0	Diarrhoea ≤ 500 mL/day	Diarrhoea <10 mL/kg/day or <4 episodes/day†
	1	Diarrhoea >500 mL/day	Diarrhoea 10–19.9 mL/kg or 4–6 episodes/day†
	2	Diarrhoea >1,000 mL/day	Diarrhoea 20–30 mL/kg/day or 7–10 episodes/day†
	3	Diarrhoea >1,500 mL/day	Diarrhoea >30 mL/kg/day or >10 episodes/day†
	4	Severe abdominal pain with or without ileus	Severe abdominal pain with or without ileus or grossly bloody stools (regardless of stool volume)

Adapted with permission from Schoemans et al. (70).

^*Anorexia accompanied by weight loss, nausea lasting ≥3 days or accompanied by ≥2 vomiting episodes per day for ≥2 days.

^†One episode of diarrhoea in children weighing <50 kg is considered equivalent to 3 mL/kg. aGvHD, acute graft versus host disease; BSA, body surface area; GI, gastrointestinal; IBMTR, International blood and marrow transplant registry; MAGIC, Mount sinai acute GvHD international consortium.