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. 2022 Jan 20;2022(1):CD001970. doi: 10.1002/14651858.CD001970.pub6

Salas 2018.

Study characteristics
Methods Randomised controlled trial
Participants Preterm infants (< 29 weeks', appropriate weight for gestation)
Neonatal Unit, Beth Israel Deaconess Medical Center, Boston, and University of Alabama at Birmingham Hospital, USA (2016 to 2017)
Interventions Delayed progressive enteral feeding (> 96 hours after birth, 30 infants) versus earlier enteral feeding (< 48 hours, 30 infants), with feed volumes advanced by 24  mL/kg/d
Infants received expressed maternal milk (first choice), pasteurised donor human milk (second choice), or artificial formula (third choice).
Outcomes
  • NEC (Bell stage 2/3)

  • Mortality

  • Invasive infection

  • Duration of hospitalisation

Notes Mean gestation at birth: 26 weeks'
Mean birth weight: 833 g
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated sequence
Allocation concealment (selection bias) Low risk Opaque sealed envelopes
Blinding of participants and personnel (performance bias)
All outcomes High risk Unmasked
Blinding of outcome assessment (detection bias)
All outcomes High risk Unmasked
Incomplete outcome data (attrition bias)
All outcomes Low risk Near‐complete cohort
Selective reporting (reporting bias) Low risk Unlikely
Other bias Low risk No evidence baseline imbalance