Salas 2018.
Study characteristics | ||
Methods | Randomised controlled trial | |
Participants | Preterm infants (< 29 weeks', appropriate weight for gestation) Neonatal Unit, Beth Israel Deaconess Medical Center, Boston, and University of Alabama at Birmingham Hospital, USA (2016 to 2017) |
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Interventions | Delayed progressive enteral feeding (> 96 hours after birth, 30 infants) versus earlier enteral feeding (< 48 hours, 30 infants), with feed volumes advanced by 24 mL/kg/d Infants received expressed maternal milk (first choice), pasteurised donor human milk (second choice), or artificial formula (third choice). |
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Outcomes |
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Notes | Mean gestation at birth: 26 weeks' Mean birth weight: 833 g |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated sequence |
Allocation concealment (selection bias) | Low risk | Opaque sealed envelopes |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Unmasked |
Blinding of outcome assessment (detection bias) All outcomes | High risk | Unmasked |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Near‐complete cohort |
Selective reporting (reporting bias) | Low risk | Unlikely |
Other bias | Low risk | No evidence baseline imbalance |