Srinivasan 2017.
Study characteristics | ||
Methods | Randomised controlled trial | |
Participants | 32 preterm (< 37 weeks' gestation) infants with evidence of intrauterine growth restriction associated with absent or reversed end‐diastolic flow velocities in antenatal Doppler studies of the umbilical artery Setting: Neonatal Unit, KEM Hospital, Mumbai, India (2016 to 2017) |
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Interventions | Delayed enteral feeding (120 to 143 hours after birth, 16 infants) versus earlier enteral feeding (24 to 48 hours after birth, 16 infants) All infants received a combination of maternal or donor human milk. |
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Outcomes |
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Notes | Mean birth weight: 1139 g (SD 263 g) Mean gestation at birth: 32 weeks' *one episode of NEC occurred‐ associated with intestinal perforation |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated sequence |
Allocation concealment (selection bias) | Low risk | Opaque sealed envelopes |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Unmasked |
Blinding of outcome assessment (detection bias) All outcomes | High risk | Unmasked |
Incomplete outcome data (attrition bias) All outcomes | Low risk | All data were included in the analyses |
Selective reporting (reporting bias) | Low risk | Unlikely |
Other bias | Low risk | No evidence baseline imbalance |