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. 2022 Jan 20;2022(1):CD001970. doi: 10.1002/14651858.CD001970.pub6

Srinivasan 2017.

Study characteristics
Methods Randomised controlled trial
Participants 32 preterm (< 37 weeks' gestation) infants with evidence of intrauterine growth restriction associated with absent or reversed end‐diastolic flow velocities in antenatal Doppler studies of the umbilical artery
Setting: Neonatal Unit, KEM Hospital, Mumbai, India (2016 to 2017)
Interventions Delayed enteral feeding (120 to 143 hours after birth, 16 infants) versus earlier enteral feeding (24 to 48 hours after birth, 16 infants)
All infants received a combination of maternal or donor human milk.
Outcomes
  • NEC (not defined)*

  • Mortality

  • Feed intolerance

  • Invasive infection

  • Days to full enteral feeds

  • Duration of hospital stay

Notes Mean birth weight: 1139 g (SD 263 g)
Mean gestation at birth: 32 weeks'
*one episode of NEC occurred‐ associated with intestinal perforation
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated sequence
Allocation concealment (selection bias) Low risk Opaque sealed envelopes
Blinding of participants and personnel (performance bias)
All outcomes High risk Unmasked
Blinding of outcome assessment (detection bias)
All outcomes High risk Unmasked
Incomplete outcome data (attrition bias)
All outcomes Low risk All data were included in the analyses
Selective reporting (reporting bias) Low risk Unlikely
Other bias Low risk No evidence baseline imbalance