Figure 3.

Allosteric signaling to the RBM

(A) The average modulation ranges at A.RBM residues upon a single mutation in different regions (except the A.RBM itself and A.RBD) in the open state.

(B) Illustration of the effects of signaling from individual residues along with their average modulation ranges in the A.RBM residues in the open state.

(C) Same as (A) for closed state.

(D) Same as (B) for closed state. The complete data are available in Figure S3. The triangles mark perturbed regions that cause the same modulation mode in both states. The illustration at the center summarizes the signaling targeting A.RBM from various locations.