Figure 4.

Allosteric signaling from glycosylated positions

(A) Center: glycosylated residues are depicted as spheres on the open spike homotrimer. Sides: examples of allosteric modulation originating from different glycosylation sites. The average modulation range ($\Delta h_{site}$) of residues within every responding site/region is provided in full in Figure S4.

(B) The glycosylated positions that can cause strong modulation ($\Delta h$, kcal/mol) in multiple sites/regions (with the average $\left|\Delta h_{site}\right|$ in all sites/regions above 0.2 kcal/mol).