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. 2022 Jan 20;30(4):590–607.e4. doi: 10.1016/j.str.2021.12.011

Figure 8.

Figure 8

Two sides of the coin: mutability and druggability as a manifestation of the “dark” and “bright” sides of viral protein dynamics

The dark side: Mutations can lead to new VOCs. The bright side: Druggable allosteric sites can be targeted, and rescue mutations can neutralize the effect of the harmful ones.