Table 4.
Nucleotide mutation and amino acid substitution in HPV-52 E6
| HPV-52 E6 | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 |
| Location | 61 | 82 | 93 | 118 | 136 | 136 | 230 | 237 | 249 | 255 | 265 | 270 | 277 | 277 | 278 | 315 | 315 | 366 | 381 | 412 | 429 |
| Mutation | G–A | C–T | G–C | A–C | C–G | C–T | G–A | T–C | G–T | G–A | G–A | G–A | A–C | A–G | A–G | T–G | T–A | C–A | T–A | G–A | A–G |
| Frequency (%) | 0.70 | 0.70 | 0.70 | 0.70 | 0.70 | 2.10 | 0.70 | 0.70 | 85.40 | 9.70 | 0.70 | 0.70 | 1.40 | 2.10 | 84.00 | 0.70 | 0.70 | 0.70 | 0.70 | 0.70 | 2.80 |
| Substitution | E21K | – | – | – | L46V | L46V | R77K | – | – | – | E89K | – | K93R | K93R | K93R | I105M | I105M | N122K | N127I | E138K | – |
Compared with the HPV-52 E6 reference sequence (NC001592), the mutations are marked with the corresponding bases and amino acid, and those without changes are replaced with a dash (–). No. means the number of nucleotide mutations, Location means the sites of nucleotide mutations, Mutation means the style of nucleotide mutations, Frequency (%) means the percentage of nucleotide mutations, Substitution means the amino acid substitution that occurred by nucleotide mutations