Table 8.
Effect of Amino-acid substution on T-cell epitopes of HPV-31 E6
| Substution | HPV-31 E6 | ||
|---|---|---|---|
| Epitopes | Alles | Effection | |
| H60Y | 52-62IVYRDDTPYGV | HLA-A*02:01 | Affinity decreased |
| 54-62YRDDTPYGV | HLA-C*08:01 | ||
| 52-60IVYRDDTPY | HLA-B*15:02 | New epitopes | |
| 51-60TIVYRDDTPY | HLA-B*15:02 | ||
| 52-60IVYRDDTPY | HLA-B*46:01 | ||
| 52-60IVYRDDTPY | HLA-C*03:02 | ||
| 57-65DTPYGVCTR | HLA-A*33:03 | ||
| 53-62VYRDDTPHGV | HLA-A*24:02 | Disappear | |
| 55-65RDDTPHGVCTK | HLA-A*11:01 | ||
| T64A | 55-65RDDTPHGVCTK | HLA-A*11:01 | Disappear |
| K65R | 65-76RCLRFYSKVSEF | HLA-A*24:02 | Better affinity |
| 57-65DTPHGVCTR | HLA-A*33:03 | New epitopes | |
| 65-79RCLRFYSKVSEFRWY | HLA-DPA1*01:03/DPB1*04:01 | ||
| 55-65RDDTPHGVCTK | HLA-A*11:01 | Disappear | |
| K123R | 117-125RHLDKKRRF | HLA-A*24:02 | New epitopes |
| A138V | 132-140WTGRCIVCW | HLA-B*58:01 | New epitopes |