Table 9.
Effect of Amino-acid substution on T-cell epitopes of HPV-33 E6
| Substution | HPV-33 E6 | ||
|---|---|---|---|
| Epitopes | Alles | Effection | |
| K35N | 35-43KPLQRSEVY | HLA-C*03:02 | Disappear |
| 35-49NPLQRSEVYDFAFAD | HLA-DQA1*01:01/DQB1*02:01 | Affinity decreased | |
| S74T | 68-76RFLSKITEY | HLA-B*46:01 | Better affinity |
| 69-76FLSKITEY | HLA-B*46:01 | ||
| 69-77FLSKITEYR | HLA-A*33:03 | ||
| 68-77RFLSKITEYR | HLA-A*33:03 | ||
| 68-76RFLSKITEY | HLA-B*15:02 | ||
| 68-76RFLSKITEY | HLA-A*24:02 | ||
| 68-76RFLSKITEY | HLA-C*03:02 | ||
| 69-76FLSKITEY | HLA-C*03:02 | ||
| 62-76ICKLCLRFLSKISEY | HLA-DRB1*14:01 | Disappear | |
| 69-79FLSKISEYRHY | HLA-B*15:02 | ||
| 74-83SEYRHYNYSV | HLA-B*40:01 | ||
| 73-81ITEYRHYNY | HLA-C*03:02 | Affinity decreased | |
| 63-77CKLCLRFLSKITEYR | HLA-DRB1*12:02 | ||
| 64-78KLCLRFLSKITEYRH | HLA-DRB1*12:02 | ||
| 62-76ICKLCLRFLSKITEY | HLA-DRB1*12:02 | ||
| 61-75GICKLCLRFLSKITE | HLA-DRB1*12:02 | ||
| 65-79LCLRFLSKITEYRHY | HLA-DRB1*12:02 | ||
| 60-74FGICKLCLRFLSKIT | HLA-DRB1*12:02 | ||
| 66-80CLRFLSKITEYRHYN | HLA-DRB1*12:02 | ||
| 64-78KLCLRFLSKITEYRH | HLA-DRB1*14:01 | ||
| 63-77CKLCLRFLSKITEYR | HLA-DRB1*14:01 | ||
| 65-79LCLRFLSKITEYRHY | HLA-DRB1*14:01 | ||
| N86H | 81-88YSVYGHTL | HLA-C*03:02 | Better affinity |
| 81-88YSVYGHTL | HLA-C*01:02 | ||
| 81-88YSVYGHTL | HLA-C*03:04 | ||
| 81-88YSVYGHTL | HLA-C*08:01 | ||
| 80-88NYSVYGHTL | HLA-A*24:02 | ||
| 78-88HYNYSVYGHTL | HLA-A*24:02 | ||
| 79-88YNYSVYGHTL | HLA-A*24:02 | ||
| N86H | 82-92SVYGHTLEQTV | HLA-A*02:01 | Better affinity |
| 83-92VYGHTLEQTV | HLA-A*24:02 | Affinity decreased | |
| 84-92YGHTLEQTV | HLA-C*08:01 | ||
| 77-88RHYNYSVYGHTL | HLA-A*24:02 | New epitopes | |
| 82-90SVYGHTLEQ | HLA-A*11:01 | ||
| 81-88YSVYGHTL | HLA-B*46:01 | ||
| 80-88NYSVYGHTL | HLA-C*01:02 | ||
| N86H/K93N | 86-94HTLEQTVNK | HLA-A*11:01 | Better affinity |
| 85-94GHTLEQTVNK | HLA-A*11:01 | ||
| 86-94HTLEQTVNK | HLA-A*33:03 | ||
| 83-94VYGHTLEQTVNK | HLA-A*11:01 | Affinity decreased | |
| 86-96HTLEQTVNKPL | HLA-B*40:01 | New epitopes | |
| 82-93SVYGNTLEQTVK | HLA-A*11:01 | Disappear | |
| K93N | 88-96LEQTVNKPL | HLA-B*40:01 | Better affinity |
| 85-94GNTLEQTVNK | HLA-A*11:01 | ||
| 86-94NTLEQTVNK | HLA-A*11:01 | ||
| 86-94NTLEQTVNK | HLA-A*33:03 | Affinity decreased | |
| 91-102TVNKPLNEILIR | HLA-A*33:03 | ||
| 83-94VYGNTLEQTVNK | HLA-A*11:01 | ||
| 82-94SVYGNTLEQTVNK | HLA-A*11:01 | ||
| 91-99TVNKPLNEI | HLA-C*08:01 | New epitopes | |
| 91-99TVNKPLNEI | HLA-B*13:01 | ||
| 91-99TVNKPLNEI | HLA-C*03:04 | ||
| 91-99TVNKPLNEI | HLA-C*01:02 | ||
| 87-96TLEQTVNKPL | HLA-B*40:01 | ||
| 82-93SVYGNTLEQTVK | HLA-A*11:01 | Disappear | |
| Q113R | 113-121REKKRHVDL | HLA-B*40:01 | Better affinity |
| R145I | 141-149RSRRIETAL | HLA-C*03:04 | Better affinity |
| 141-149RSRRRETAL | HLA-C*01:02 | Disappear | |