Table 2.
Regression coefficients and corresponding weights
| C9orf72 | GRN | MAPT | ||||
|---|---|---|---|---|---|---|
| Coef. | Weight | Coef. | Weight | Coef. | Weight | |
| Language | ||||||
| Camel and Cactus Test | − 0.004 | 0.003 | − 0.04 | 0.04 | ||
| Boston Naming Test | − 0.39 | 0.40 | ||||
| Category fluency | − 0.13 | 0.09 | ||||
| Attention and mental processing speed | ||||||
| Digit span forward | ||||||
| Trail Making Test – part A | ||||||
| Digit symbol | ||||||
| D-KEFS CWIT – colour naming | − 0.06 | 0.04 | − 0.09 | 0.09 | ||
| D-KEFS CWIT – word naming | − 0.04 | 0.03 | 0.09a | |||
| Executive function | ||||||
| Digit span backward | ||||||
| Trail Making Test – part B | − 0.07 | 0.05 | − 0.28 | 0.23 | ||
| D-KEFS CWIT – ink naming | − 0.29 | 0.20 | − 0.24 | 0.20 | ||
| Phonemic fluency | 0.24a | |||||
| Visuoconstruction | ||||||
| Benson figure copy | − 0.09 | 0.06 | ||||
| Memory | ||||||
| Benson figure recall | − 0.06 | 0.05 | − 0.01 | 0.01 | ||
| FCSRT free recall | − 0.50 | 0.35 | − 0.06 | 0.06 | ||
| FCSRT total recall | − 0.05 | 0.04 | − 0.30 | 0.31 | ||
| FCSRT delayed free recall | − 0.16 | 0.13 | − 0.01 | 0.01 | ||
| FCSRT delayed total recall | ||||||
| Social cognition | ||||||
| Facial Emotion Recognition Test | − 0.26 | 0.18 | − 0.42 | 0.35 | − 0.08 | 0.08 |
Data are presented as coefficients and weights. Coefficient gives the change in log odds of being a mutation carrier for each Z-score increase in the score on the cognitive test. Weight gives the weighting used when calculating the weighted cognitive composite score
Abbreviations: C9orf72 chromosome 9 open reading frame 72, GRN progranulin, MAPT microtubule-associated protein tau, D-KEFS CWIT Delis-Kaplan Executive Function System Colour-Word Interference Test, FCSRT Free and Cued Selective Reminding Test
aPositive coefficients indicate better performance in mutation carriers compared to controls and were not included in the composite score