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. 2022 Jan 20;22:83. doi: 10.1186/s12885-022-09183-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — PFKFB3 protein is overexpressed in human ccRCC specimens and positively correlates with late TNM stage and low prognostic odds in ccRCC cases. (a) Representative images of juxta-tumoral healthy biopsies with down-regulated PFKFB3 expression. (b) ccRCC biopsy imaging, with high expression of PFKFB3. (c) H-score plot for PFKFB3 in ccRCC tissues (n = 90) and adjacent normal tissues (n = 90). (ccRCC = 131.52 ± 5.61 vs. Normal = 72.36 ± 4.55, P < 0.01). (d-e) H-score of PFKFB3 at multiple stages (TMN) and grades (Fuhrman) in ccRCC cases. (f) Kaplan-Meier overall survival times in ccRCC cases based on PFKFB3 expression (mean ± SD. *, P < 0.05; **, P < 0.01)