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. Author manuscript; available in PMC: 2022 Jan 20.
Published in final edited form as: Neurobiol Dis. 2020 Feb 28;139:104823. doi: 10.1016/j.nbd.2020.104823

Fig. 5.

Fig. 5.

SWI hypointensities. (A) Representative SWI images at days 2 and 14 posttreatment in male/female and control/immunized Tg-SwDI mice (n = 8/group). No differences were apparent visually. (B) Anterior-posterior quantification of the SWI hypo-intensities at day 2 post-immunization revealed no significant differences between male and female groups (two-way ANOVA, Tukey's multiple comparisons). C) The average number of hypo-intensities over the whole brain was assessed at day 2 within the brains of treated Tg-SwDI mice and did not differ among groups. (D) There were no significant differences in SWI hypo-intensities at day 14 post-immunization in males and females. However, both control and immunized males at the level of the dorsal hippocampus had significantly increased hypo-intensities (slice 5) compared to control and immunized females (two-way ANOVA, Tukey's multiple comparisons, ***p < .001). E) When the average numbers of hypo-intensities were evaluated at day 14 after treatment across all MRI slices, no significant differences were observed, n = 8/group.