TABLE 3.
Echocardiographic outcomes before and after cardiac resynchronization therapy in patients with chemotherapy-induced cardiomyopathy and patients with other types of non-ischemic cardiomyopathy
| Control (n = 58) | CHIC (n = 28) | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable | Pre CRT | After CRT | Mean difference | p | Pre CRT | After CRT | Mean difference | p |
| LVEF, mean (%) | 28 ± 7 | 38 ± 13 | 10 | < .001 | 28 ± 8 | 38 ± 10 | 10 | < .001 |
| LVEDD, mean (mm) | 63 ± 9 | 61 ± 11 | −2 | .065 | 60 ± 8 | 56 ± 8 | −4 | .006 |
| LVESD, mean (mm) | 54 ± 10 | 49 ± 13 | −5 | < .001 | 52 ± 8 | 45 ± 8 | −7 | .002 |
| LVEDV, mean (mL) | 202.4 ± 91.9 | 162.4 ± 75.3 | −40 | <.0001 | 206.8 ± 76.4 | 165.3 ± 52.7 | −41.5 | .065 |
| LVESV, mean (mL) | 144.4 ± 82.6 | 105.7 ± 68.2 | −38.7 | <.0001 | 148.4 ± 64.7 | 94.8 ± 38.5 | −53.6 | .109 |
| RVSP, mean (mmHg) | 40 ± 13 | 37 ± 11 | −2 | .216 | 37 ± 15 | 37 ± 11 | −0.2 | .962 |
| RVE, mean | 0.69 ± 0.88 | 0.73 ± 0.70 | 0.07 | .324 | 0.72 ± 0.92 | 0.78 ± 0.93 | 0.04 | .746 |
| RV dysfunction, mean | 0.91 ± 0.98 | 0.65 ± 0.82 | −0.18 | .236 | 0.68 ± 0.94 | 0.78 ± 0.97 | 0.07 | .252 |
| MR, mean | 1.54 ± 1.40 | 1.18 ± 1.40 | −0.315 | .077 | 1.14 ± 1.09 | 0.82 ± 0.86 | −0.29 | .183 |
Abbreviations: CHIC, chemotherapy-induced cardiomyopathy; CRT, cardiac resynchronization therapy; LVESD, left ventricular end systolic diameter; LVEDD, left ventricular end diastolic diameter; LVESV, left ventricular end systolic volume; LVEDV, left ventricular end diastolic volume; LVEF, left ventricular ejection fraction; RVSP, right ventricular systolic pressure; RVE, right ventricular enlargement; RV, right ventricular; MR, mitral regurgitation.