Table 3.

Multivariable analyses of time to AF in patients with no AF at ibrutinib start (n = 290) and in the subset with no prior history of AF (n = 269)

Parameter	At risk for AF (n = 290)		No prior history of AF (n = 269)
	HR (95% CI)	p value	HR (95% CI)	p value
Age > = 65	1.79 (0.84–3.83)	0.13	2.20 (0.90–5.39)	0.08
Hypertension	1.04 (0.53–2.03)	0.92	1.15 (0.49–2.70)	0.74
Heart failure	3.42 (1.53–7.66)	0.003	2.51 (0.98–6.42)	0.06
Valvular heart disease	1.36 (0.54–3.40)	0.51	2.48 (0.95–6.46)	0.06
History of AF	3.48 (1.42–8.66)	0.007

Italicized table entries indicate P-value < 0.05