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Dose reductions to the left anterior descending artery (pink) and aortic valve (brown) by including cardiac substructures in the optimization for patients receiving mediastinal radiation therapy, 40 Gy in 20 fractions, for a chemo-refractory diffuse large B-cell lymphoma. In the dose-volume histogram, the squares correspond with the cardiac substructure–sparing plan, and the triangles correspond with the noncardiac substructure–sparing plan.
