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. 2022 Jan 19;10(1):e004034. doi: 10.1136/jitc-2021-004034

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Subsets of CD8 +TILs differentially respond to ICB. (A) Diffusion pseudotime of indicated CD8 +T cell major subsets in distinct treatment conditions. (*P<0.05, **p<0.01, ***p<0.001, ****p<0.0001). Significance was calculated by one-way ANOVA.) (B) Heatmap of TCR clone size. Cells were colored by TCR clone size on a log2 scale in the UMAP of T cells in indicated conditions of MOC1esc1 tumors. (C) Shared fraction analysis heatmaps of TCR clonotypes between primary and secondary phenotypes in indicated conditions of MOC1esc1 tumors. ANOVA, analysis of variance; ICB, immune checkpoint blockade; MOC1, murine oral carcinoma; TILs, tumor infiltrating lymphocytes; UMAP, uniform manifold approximation and projection.