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. Author manuscript; available in PMC: 2022 Jan 20.
Published in final edited form as: Clin Cancer Res. 2020 Apr 24;26(15):4018–4030. doi: 10.1158/1078-0432.CCR-19-3416

Figure 3.

Figure 3.

Immune cell densities. A, Densities (immune cells/mm2) for CD3 (T cells), CD8 (cytotoxic T cells), Foxp3 (T-regulatory cells), and CD163 (TAMs) were plotted in UPS, ERMS, and ARMS specimens. TAMS have the strongest presence in all sarcomas, with UPS having the greatest density, followed by ERMS, and then ARMS (*, P < 0.0001; **, P = 0.0003; ***, P = 0.0072 by paired t test). B, Normalization of CD163 densities to CD3 densities with CD163/CD3 ratio among the three different STS subtypes. CD163/CD3 ratio in UPS specimens are higher than rhabdomyosarcoma subtypes, both ARMS and ERMS, but there is no difference between ARMS and ERMS (*, P = 0.0009; **, P = 0.0010). C, Percent surface area covered by CSF1R was measured in the three subtypes. UPS specimens have the highest percent of CSF1R expression, followed by ARMS, and then ERMS (*, P < 0.0001; **, P < 0.0001; ***, P = 0.01 by paired t test). D, Mean surface area covered by PD-L1 was highest in UPS specimens, but only statistically significant when compared with mean of ERMS specimens (**, P < 0.0001). ns, nonsignificant (P > 0.05).