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. 2022 Jan 13;11(1):97. doi: 10.3390/antibiotics11010097

Figure 2.

Figure 2

Phylogeny of 91 MCR-1 proteins of E. coli origin retrieved from NCBI database including the six sequenced SAUVM MCR-1 genes from this study. Phylogenetic study of MCR-1 and MCR-1-like proteins reveals ancestral origins and diversification. Using amino acid sequences from six SAUVM MCR-1 proteins, the BLAST search tool (https://blast.ncbi.nlm.nih.gov/Blast.cgi accessed on 16 March 2021) was used to retrieve homologous sequences of MCR-1 and MCR-1-like proteins from the NCBI database. MCR-1 and MCR-1-like proteins of Salmonella, E. coli, strains containing LptA (formerly known as EptA), and other sequences were categorized. Using aligned MCR-1 sequences from CLUSTALW, the maximum likelihood method of MEGA X was used to create a phylogenetic tree.