Table 1.
Individual comparisons between the four curves shown in Figure 5b. Kaplan–Meier estimates of OS according to TAC plasma levels and type of mutations (Figure S2 shows individual extended data). Differences between two survival curves was evaluated by log-rank (Mantel–Cox) test. Hazard ratio was computed to determine the magnitude of difference between two curves. 95% CI, 95% confidence interval. Significant log-rank p values (p < 0.05) are represented in bold.
| Comparison | Overall Survival | |
|---|---|---|
| Hazard Ratio (95% CI) | p | |
| Low TAC–JAK2 vs. High TAC–JAK2 | 2.487 (1.218–5.079) | 0.0068 |
| Low TAC–CALR vs. High TAC–CALR | 5.240 (1.562–17.58) | 0.0694 |
| Low TAC–JAK2 vs. Low TAC–CALR | 0.2756 (0.07882–0.9635) | 0.1758 |
| High TAC–JAK2 vs. High TAC–CALR | 0.6290 (0.3073–1.288) | 0.2132 |
| Low TAC–JAK2 vs. High TAC–CALR | 1.440 (0.6341–3.271) | 0.3563 |
| Low TAC–CALR vs. High TAC–JAK2 | 9.265 (3.642–23.57) | 0.0076 |