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. 2021 Dec 22;10(1):8. doi: 10.3390/biomedicines10010008

Figure 2.

Figure 2

The combination of CD276 and TIM-3 was an independently poor prognostic biomarker of UC. (A) Univariate overall survival of 224 UC patients from GSE32894 was grouped by double-negative low, single-positive medium and double-positive high CD276 and TIM3 expression using the median value as the cut-off. The CD276TIM3 double-positive group consisted of 60 patients (red line), the CD276 and TIM3 single or double-negative group consisted of 164 patients (blue line). Kaplan-Meier survival analysis was performed. (B) Multivariate Cox regression survival plot of 224 UC patients from GSE32894 was grouped as (A) described. (C) Results of the multivariate analysis from (B). (D) Multivariate Cox regression recurrent-free survival plot of 93 UC patients from GSE31684 was grouped by lower + medium (n = 63) and higher (n = 30) CD276TIM3 as (A) described. (E) Results of the multivariate analysis from (D). The p values were calculated by the log-rank test.