Table 3.

Variables associated with early nephrotoxicity in univariate and multivariate analyses.

Factors	No of Patients with Early Nephrotoxicity (%)		p Value by Univariate Analysis	Adjusted Odds Ratio (95% Confidence Interval)	p Value by Multivariate Analyses
	Patients with Factor	Patients without Factor
Day 2 AUC ≥ 600 µg·h/mL	4/13 (30.8%)	3/247 (1.2%)	<0.001	44.77 (6.65–301.65)	<0.001
Concomitant piperalin/tazobactam	5/54 (9.3%)	2/206 (1.0%)	0.005	12.93 (1.87–89.49)	0.010

AUC: area under the concentration–time curve.