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. 2021 Dec 27;11(1):56. doi: 10.3390/antiox11010056

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Met-OLE inhibited (A) MAPKs phosphorylation and (B) upregulated the Nrf-2/HO-1 antioxidation axis in LPS-induced cells. Macrophages were pretreated and stimulated with LPS during 18 h with met-OLE (50, 25 or 12.5 μM). Subsequently, MAPKs, Nrf-2, and HO-1 protein expressions were measured in whole cell lysates by Western blot. Results are presented as the mean ± SEM of at least six independent experiments. + p < 0.05; ++ p < 0.01; +++ p < 0.001 vs. unstimulated control cells; * p < 0.05; ** p < 0.01; *** p < 0.001 vs. LPS-DMSO stimulated cells.