Figure 4.

Schematic representation of the mammary cellular plasticity during tumorigenesis. The use of different murine Cre lines (Lgr5-Cre^ERT2, Krt5-Cre^ERT2 or Krt14-Cre to target BCs; Bgl-Cre or Wap-Cre to trace ERα^neg LCs; and Esr1-Cre to monitor ERα^pos LCs) to induce the expression of specific mutations in different mammary epithelial cell types resulted in the generation of tumors that resembled some of the human subtypes: luminal A [43], luminal B [43,89], HER2-enriched [48,66], claudin-low (or mesenchymal-like) [96], and basal-like [18,73] tumors. Notes: this figure only includes studies that have used comparisons with human breast cancer transcriptomic datasets (PAM50, Hu306 or similar); studies performed with non-specific Cre lines, such as MMTV-Cre or Krt8-Cre^ERT2 (which labels all MECs, or both LC populations, respectively), were discarded. This figure was created with Biorender.com (accessed on 12 December 2021).