Table 1.

Murine models that recapitulate different human breast cancer subtypes. This table summarizes the transcriptomic analysis performed in tumors derived from different murine in vivo models that are able to resemble specific human breast cancer subtypes.

Mouse Model	Oncogenic Expression	Human Breast Cancer Subtype	Ref.
MMTV-Wnt1	Wnt1 overexpression	Basal-like	[75]
WAP-Tag	SV40 large T antigen	Basal-Like	[74]
WAP-Int3	Notch 4 overexpression	Luminal-Like	[78]
MMTV-Hras	Hras overexpression	Luminal A	[72]
MMTV-PyMT	Activation of Src, PI3K, and Shc	Luminal B	[77]
MMTV-Neu	Inactivated rat ErbB2 overexpression in MECs	HER2-enriched	[76]
WAP-Cre/Etv6	Etv6-Ntrk3 fusion gene overexpression	HER2-enriched	[82]
Brg1+/−	Brg1 heterozygous	HER2-enriched	[79]
p18−/−	Cdkn2c homozygous null	HER2-enriched	[80]
Rb−/−	Rb homozygous null	HER2-enriched	[80]
MMTV-Fgf3	Fgf3 overexpression	HER2-enriched	[83]
MMTV-Lpa	Lpa1, Lpa2, or Lpa3 overexpression	Mesenchymal-like	[69]
p53+/− irradiated	Trp53 heterozygous, irradiated	Mesenchymal-like	[71]
DMBA-induced	Random DMBA induction	Basal-like Mesenchymal-like	[68]
C3(1)-Tag	pRb, p107, p130, p53, p300 inactivation and others in MECs	Basal-like Mesenchymal-like	[44]
WAP-Myc	Myc overexpression in LCs	Basal-like Luminal B	[73]
MMTV-Myc	Myc overexpression	Basal-like Luminal B	[72]
MMTV-Cre/Brca1Co/Co/p53+/−	Brca1 truncation in MECs, Tp53 heterozygous null	Basal-like Mesenchymal-like	[67]
MMTV-Aib1	Aib1 overexpression	Basal-Like Luminal B HER2-enriched	[69]
WAP-T121	pRb, p107 and p130 inactivation in LCs	HER2-enriched Mesenchymal-like	[70]