Table 2.

Ongoing clinical trials in COVID-19 patients with drugs that target a phase of the process of neutrophil extracellular trap (NETs) release.

Target	Drug	NTC Number	Patients					Outcome Measures
			ICU	Hospitalized	Outpatients	Asymptomatic	Specific Conditions	VL/Clearance	Biomarkers	Others
Neutrophil	Colchicine	NCT04363437		X					Cardiac and Inflammatory
		NCT04756128		X
		NCT04492358		X
		NCT04403243		X					Coagulatory and Inflammatory
		NCT04367168		X
		NCT04724629		X			Pneumonia		Coagulatory and Inflammatory
		NCT04375202		X			Pneumonia
		NCT04359095		X			Pneumonia
		NCT04762771 †		X			Cardiac injury		Cardiac and Inflammatory
		NCT04510038 †		X			Cardiac injury		Cardiac and Inflammatory
		NCT04355143		X			Cardiac injury		Inflammatory
		NCT04603690		X				X	Coagulatory and Inflammatory
		NCT04360980		X				X	Inflammatory
		NCT04818489		X					Inflammatory
		NCT04472611		X
		NCT04539873		X
		NCT04381936 *		X						Renal and Thrombotic complications
		NCT04324463		X	X
		NCT04416334			X		With risk factors
		NCT04516941			X			X
		NCT04322565			X	X	With risk factors
NETs release	Fostamatinib	NCT04581954		X			Pneumonia
		NCT04629703		X			Without respiratory failure and with risk factors
DNA	Dornase alfa	NCT04355364	X	X	X		ARDS
		NCT04359654		X			Systemic inflammation at risk of ventilatory failure		Inflammatory
		NCT04432987	X	X
		NCT04445285	X	X
		NCT04488081	X	X
		NCT04402944 *	X				Pneumonia
NE	Alvelestat	NCT04539795			X				Inflammatory
Gasdermin D	Disulfiram	NCT04594343		X					Coagulatory, Inflammatory and NETs
		NCT04485130		X				X	Inflammatory
HMGB1	Metformin	NCT04626089		X	X			X	Cardiac
		NCT04604678			X
		NCT04510194			X			X	Inflammatory
ROS	Cholecalciferol	NCT04636086		X				X	Inflammatory
		NCT04399746			X			X
	N-acetylcysteine	NCT04755972	X
		NCT04374461	X	X
		NCT04792021		X					Inflammatory
		NCT04703036		X					Inflammatory
		NCT04928495			X			X	Cardiac, coagulatory and inflammatory
	Vitamin D	NCT03188796	X				Severe Vitamin D defficiency
		NCT04952857		X
		NCT04395768		X
		NCT04525820		X
		NCT04552951 *		X				X	Cardiac, coagulatory and inflammatory
		NCT04641195		X					Cardiac and inflammatory
		NCT04502667 *		X					Coagulatory and inflammatory
		NCT04621058 *					Vitamin D defficiency
		NCT04385940		X	X		With risk factors		Inflammatory
		NCT04334512			X
		NCT04386850			X
		NCT04780061			X
		NCT04489628			X
		NCT04868903			X
		NCT04363840			X
		NCT04482686			X				Inflammatory
		NCT04334005			X
		NCT04351490			X	X
		NCT04536298			X					Infection prevention
		NCT04476680				X
		NCT04482673			X		Negative/Positive PCR		Inflammatory	Infection prevention
		NCT04828538			X		Negative PCR/Symptomatic with risk factors			Infection prevention
		NCT04535791					Negative/Positive PCR HCW			Infection prevention
		NCT04372017					With high risk of contact and HCW			Infection prevention
		NCT04335084					With high risk of contact and HCW			Infection prevention
		NCT04596657					With high risk of contact and HCW			Infection prevention
		NCT04979065					Negative PCR HCW with overweight and obesity		Inflammatory	Infection prevention
		NCT04476745					Negative PCR with Vitamin D defficency		Inflammatory
		NCT04825093					Pregnant
		NCT04579640					Not specificed
		NCT04734886					Not specificed		Inflammatory

ICU: intensive care unit; VL: viral load; NETs: neutrophil extracellular traps; NE: neutrophil elastase; HMGB1: high-mobility group box 1; ROS: reactive oxygen species; HCW: healthcare workers. * Child patients. ^† Suspended.