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. 2022 Jan 3;10(1):96. doi: 10.3390/biomedicines10010096

Table 1.

WHO classification of brain tumor grades.

Grade Tumor Types Characteristics
Low Grade Grade I
  • Craniopharyngioma

  • Chordomas

  • Ganglioglioma

  • Gangliocytoma

  • Pilocytic astrocytoma

  • Possibly curable via surgery alone

  • Long-term survival

  • Least malignant (benign)

  • Non-infiltrative

Grade II
  • Pineocytoma

  • “Diffuse” astrocytoma

  • Pure oligodendroglioma

  • Slight infiltrative

  • Relatively slow growing

  • Can recur as higher grade

High Grade Grade III
  • Anaplastic ependymoma

  • Anaplastic astrocytoma

  • Anaplastic oligodendroglioma

  • Malignant

  • Infiltrative

  • Tend to recur as higher grade

Grade IV
  • Glioblastoma multiforme

  • Medulloblastoma

  • Ependymoblastoma

  • Pineoblastoma

  • Most malignant

  • Rapidly growing and aggressive

  • Widely infiltrative

  • Recurrence

  • Tendency for necrosis