Figure 1.

Schematic representation of the metabolic strategies to target viral replication. Hexokinase inhibitors interfere with glycolysis and glucose metabolism, whereas glutaminolysis inhibitors block the glutamate formation from glutamine. The lipid metabolism can be affected with different strategies: carnitine palmitoyl transferase 1 (CPT1) inhibitors block the entry of long-chain fatty acids into mitochondria for oxidation, fatty acid synthase (FASN or FAS) and stearoyl-CoA desaturase (SCD) inhibitors strongly interfere with lipogenesis.