Illustrative diagram of the main events occurring in hepatocytes under non-alcoholic fatty liver disease (NALFD) conditions. The activation of FGF21 signaling by the phytochemicals from the cocoa shell is conducive to the regulation of lipid and glucose metabolism, via ERK, mTOR, AKT, and AMPK pathways. Harmoniously, these metabolic events lead to antioxidant enzymes stimulation and ROS reduction, and to the enhancement of mitochondrial bioenergetic functions. The blockade on liver metabolism generated by saturated fatty acids, here palmitic acid, is repressed, avoiding the development of NAFLD.