Table 2.

MICs of BBB4 as µg/mL and micromolarity (µM), against representative clinical isolates of Gram-positive and Gram-negative species, including several strains of the Staphylococcus genus. The reference strain S. aureus ATCC 29213 was also employed.

	BBB4 MW 343.2		Reference Antibiotics
	MIC Values $		MIC Values $
	µg/mL	µM	µg/mL	µM
Gram-negative enterobacteriaceae and non-fermenting bacteria
E. coli 224 #	>128	>373	8 32 16	17 1 97 2 27 3
P. aeruginosa 247	>128	>373	64	78 4
Gram-positive sporogenic
B. subtilis 394	128	373	128	212 3
Gram-positive staphylococci
S. aureus ATCC 29213	32	93	<2 5	<5 5
S. aureus 18 *	32	93	512 5	1275 5
S. aureus 191 *	32	93	512 5	1275 5
S. aureus 195 *	32	93	256 5	638 5
S. epidermidis 22 §	32	93	256 5	638 5
S. epidermidis 197 §	32	93	256 5	638 5
S. epidermidis 198 †,§	32	93	256 5	638 5
S. epidermidis 181 †,§	32	93	256 5	638 5
S. haemoliticus 193 ††	>128	>373	256 5	638 5
S. hominis 125 ††	>128	>372	256 5	638 5
S. lugdunensis 129	128	373	<2 5	<5 5
S. saprophyticus 41	32	93	<2 5	<5 5
S. symulans 163 ††	>128	>373	256 5	638 5
S. warneri 74 ††	64	187	256 5	638 5
Gram-positive enterococci
E. faecium 341 #	>128	>373	256	177 6
E. faecalis 1 #	>128	>373	128	88 6

^$ Experiments were performed in triplicate, the concordance degree was 3/3, and ±SD was zero; ^# indicates antibiotics susceptibility; P. aeruginosa was MDR; * indicates MRSA; ^§ indicates MRSE; ^† indicates MRSE also resistant to linezolid; ^# indicates VRE; ^†† indicates resistance to oxacillin; ¹ ertapenem; ² ciprofloxacin; ³ amoxy-clavulanate; ⁴ piperacillin taxobactam; ⁵ oxacillin; ⁶ vancomycin.