| IV | intravenous |
| PIV | peripheral intravenous |
| HUVEC | Human umbilical vein endothelial cells |
| VAN | vancomycin |
| Highlights | |
| Toxicity of variations in vancomycin concentration is explored. | |
| Vancomycin-induced local endothelial toxicity is dose-dependent. | |
| Variation of vancomycin concentration does not influence endothelial cell toxicity. | |
| Medium removal simulating multi-drug infusion increases endothelial cell toxicity. | |
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